Role: Assassin
Lane: Midlane
Table of Contents
Qiyana Mid performs best with a build featuring Hubris, Ionian Boots of Lucidity, Profane Hydra, Serylda's Grudge, and Edge of Night. The most effective rune setup for Qiyana Mid includes Electrocute, Sudden Impact, Grisly Mementos, and Treasure Hunter in the primary tree, paired with Last Stand and Presence of Mind in the secondary tree.
Look for fights when the enemy is close to a wall. Pushing them into it will result in a lot of damage dealt and allow your team to win the fight. Fighting in the jungle is highly preferred on Qiyana. If your Jungler comes to gank, make sure you have your River Enchantment ready (by using W on the river) to root the enemy. Qiyana is very good in the early game. Try to get a lead so you become harder to deal with in team fights.
If you want to use the most popular Qiyana Mid build, you should take Flash and Ignite as your Summoner Spells. For runes, you should pick Electrocute as your keystone, followed by Sudden Impact, Grisly Mementos and Treasure Hunter in the primary tree, as well as Last Stand and Presence of Mind in the secondary tree. For rune shards, you want Adaptive Force in offense, Adaptive Force in flex and Health Scaling in defense, though it depends on the matchup. Finally, for your items, you should build Hubris as your first item, followed by Ionian Boots of Lucidity and Profane Hydra. For your last 3 items, you should build Serylda's Grudge, Edge of Night and finish with Serpent's Fang. For the skill order, you want to stick with Q - W - E.
Your second option for Qiyana Mid build would be to take Flash and Ignite as your Summoner Spells. The runes that this build takes advantage of are Electrocute as your keystone, Sudden Impact, Grisly Mementos and Treasure Hunter in the primary tree, and Last Stand with Presence of Mind in the secondary tree. The shards used in this build are Adaptive Force in offense, Adaptive Force in flex and Health Scaling in defense. The items for the build are Youmuu's Ghostblade, which you should build first, followed by Ionian Boots of Lucidity as your second item and Profane Hydra as your third item. The rest of the items in order are Serylda's Grudge, Edge of Night and Serpent's Fang. The skill order for this build is Q - W - E.
If you're looking for alternatives, you can use Flash and Ignite as your Summoner Spells, with runes being Conqueror as your keystone, Triumph, Legend: Alacrity and Last Stand in the primary tree, and Sudden Impact with Ultimate Hunter in the secondary tree, as well as Adaptive Force, Adaptive Force, and Health as your rune shards. The items that this build incorporates are Hubris as your first item, then Ionian Boots of Lucidity as a second item and Profane Hydra as a third item. You want to finish the build with Serylda's Grudge, Serpent's Fang and Edge of Night. As far as ability max order goes, you want to keep it Q - W - E.
If you want to try an Off-Meta Qiyana Mid build in the current patch, try Flash and Ignite as your Summoner Spells, Electrocute, Sudden Impact, Grisly Mementos and Treasure Hunter as your primary rune tree, and Last Stand with Presence of Mind as your secondary tree. Use Adaptive Force, Adaptive Force and Health Scaling as your shards. For items in this build, you want to complete Profane Hydra as your first item, then finish Ionian Boots of Lucidity as your second item, and Youmuu's Ghostblade as third item. The last 3 options are Serylda's Grudge, Edge of Night and Serpent's Fang. The ability order for this build is Q - W - E.
Depending on the context of your game, your matchup, and enemy champions, you might want to consider building some situational items or take specific runes. Carefully examine your team, enemy team, game state, and your matchup to plan your Qiyana build accordingly! For example, when it comes to rune shards, you might want to take either Armor or Magic Resist, depending on which champion you are about to lane against.